Science Insights

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Systemic drug administration often causes off target effects limiting the efficacy of advanced therapies Targeted drug delivery approaches increase local drug concentrations at the

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Chimeric antigen receptor CAR T cell therapies have transformed treatment of B cell malignancies However their broader application is limited by complex manufacturing processes and

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Phenotypic drug screening remains constrained by the vastness of chemical space and the technical challenges of scaling experimental workflows To overcome these barriers

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The sense of touch conveys critical environmental information facilitating object recognition manipulation and social interaction and can be engineered through haptic actuators

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Systems that perform continuous hypermutation of designated genes without compromising the integrity of the host genome can substantially accelerate the evolution of new or

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Affective contagion a core component of empathy has been widely characterized in social vertebrates but its existence in any invertebrate is unknown Using a cognitive bias paradigm

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Science 6 Nov 2025 Vol 390 Issue 6773 pp 638 642 DOI 10 1126 science adw8780 Editor s summary Abstract Homogenized vertical chlorine distribution Surface morphology and properties

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The mouse is a tractable model for human ovarian biology however its utility is limited by incomplete understanding of how transcription and signaling differ interspecifically and with age We

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Mammals display prominent diversity in the ability to regenerate damaged ear pinna but the genetic changes underlying the failure of regeneration remain elusive We performed