Pharmacielesoustalous

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Cold agglutinin disease CAD is an autoimmune hemolytic anemia a specific clonal B cell disorder of the bone marrow and a monoclonal gammopathy of clinical significance

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To define the pathophysiologic mechanisms of cold agglutinin disease we investigated a human model of this syndrome in normal volunteers and in patients with diminished levels of serum complement

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The classical complement pathway and to some extent the terminal pathway are involved in the immune pathogenesis of autoimmune hemolytic anemia AI

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To define the pathophysiologic mechanisms of cold agglutinin disease the authors investigated a human model of this syndrome in normal volunteers and in patients with diminished levels of serum

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The immune hemolysis is entirely complement dependent predominantly mediated by activation of the classical pathway and phagocytosis of erythrocytes opsonized with complement protein C3b Typical

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Cold Agglutinin Disease an overview ScienceDirect Topics

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In the formation of the membrane attack complex several complement proteins are inserted into the red blood cell membrane forming pores that lead to membrane instability and intravascular hemolysis

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Primary Cold Agglutinin Disease CAD is a rare autoimmune hemolytic anemia It is driven by a unique pathophysiological sequence pathogenic monoclonal IgM antibodies bind to red blood cells at lower

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Subjects received intravenous injections of autologous chromated mCr erythrocytes which had been exposed in vitro to purified cold agglutinin preparations and to fresh autologous serum as a source