Matiger

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For patients who have completed the dose titration phase and are on a steady daily dose of venetoclax the dose should be reduced by at least 50 when used concomitantly with moderate CYP3A

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Patients should be instructed to drink plenty of water daily starting 2 days before and throughout the dose titration phase Patients should be particularly instructed to drink 1 5 to 2 0 L of water daily 2

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Patients should be instructed to drink plenty of water daily starting 2 days before and throughout the dose titration phase Patients should be particularly instructed to drink 1 5 to 2L of water daily 2

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Patients should drink at least 1 5 to 2 0 L of water daily starting 2 days before the first dose and throughout the dose titration phase Intravenous fluids should be administered as indicated based on

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Cycle 1 Titration of venetoclax toclax once daily for 7 days The dose must be gradually increased over a period of 5 weeks up to the rec

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Instruct patients to drink water daily starting 2 days before and throughout the dose titration phase specifically prior to and on the days of dosing at initiation and each subsequent dose increase

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Venetoclax is administered orally once daily commencing on Day 1 of Cycle 1 with a starting dose of 100mg This is increased to 200mg on Day 2 and 400mg on Day 3 and thereafter The 3 day dose

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The starting dose is 20 mg of venetoclax once daily for 7 days The dose must be gradually increased over a period of 5 weeks up to the daily dose of 400 mg as shown in Table 1 The 5 week dose

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Below are examples of dispensing scenarios by package size based on the venetoclax daily dose Please refer to the Venclexta package insert for full dosing guidance