Gelsolin

https://www.jbc.org › article › fulltext
This review has focused on the intracellular functions of gelsolin and emphasizes progress made to obtain a mechanistic model of how gelsolin regulates the actin cytoskeleton in response to

https://www.sciencedirect.com › ... › gelsolin
Gelsolin deficient mice are viable Witke et al 1995 but studies with derived gelsolin cells or cell lines have indicated that its activity is necessary for processes requiring maximal motility

https://www.nature.com › articles
Gelsolin is the prototypical member of a family of Ca2 activated F actin severing and capping proteins Here we report structures of Ca2 bound human gelsolin at the barbed

https://pubmed.ncbi.nlm.nih.gov
Gelsolin a Ca 2 regulated actin filament severing capping and nucleating protein is an ubiquitous multifunctional regulator of cell structure and metabolism

https://link.springer.com › chapter
Gelsolin is a protein that exerts a variety of influences both within the cytoplasm and in extracellular fluids reviewed in Yin 1987 Janmey et al 1998 Intracellular gelsolin

https://maciverlab.bms.ed.ac.uk › Cyto-Topics › gelsolin_family.htm
The family of which gelsolin is a member may be divided into two groups Weeds Maciver 1993 class I severing and capping proteins and the Class II capping proteins that do not

https://onlinelibrary.wiley.com › doi
Gelsolin GSN was first identified as an agent that could transform macrophage extracts from viscous gels to fluid sols subsequently accredited to its calcium sensitive ability to sever F

https://en.wikipedia.org › wiki › Plasma_gelsolin
Plasma gelsolin Plasma gelsolin pGSN is an 83 kDa abundant protein constituent of normal plasma and an important component of the innate immune system The identification of pGSN

https://pubmed.ncbi.nlm.nih.gov
In this review we summarise the structure of GSN as well as its regulating and functional roles focusing on distinct diseases such as Alzheimer s disease rheumatoid