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https://www.sciencedirect.com › science › article › pii
Genetic and epigenetic alterations in tumor cells and CAFs metabolic adaptations and the hypoxic and immunosuppressive TME are all factors involved in cancer progression and
https://pmc.ncbi.nlm.nih.gov › articles
This review discusses the molecular mechanisms that play a crucial role in PDAC therapy resistance and how a better understanding of these mechanisms has shaped clinical trials for pancreatic cancer
https://pmc.ncbi.nlm.nih.gov › articles
In this review we discuss the rationale behind some of the tumor cell autonomous and tumor microenvironment related molecular mechanisms responsible for the resistance of pancreatic cancer
https://www.thelancet.com › article › fulltext
In this regard pancreatic ductal adenocarcinoma PDAC represents a remarkable example PDAC is a devastating disease with a poor clinical outcome which is mainly due to late
https://www.frontiersin.org › journals › cell-and-developmental-biology...
Cancer associated fibroblasts mediated ATF4 expression promotes malignancy and gemcitabine resistance in pancreatic cancer via the TGF 1 SMAD2 3 pathway and ABCC1
https://www.nature.com › articles
Interactions between tumor and stromal cells are well known to play prominent roles in progression of pancreatic ductal adenocarcinoma PDAC
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